9/2/2023 0 Comments Brain neurons firing![]() ![]() ![]() “To achieve scanning fast enough to image neurons firing, we used an optical component known as a digital mirror device (DMD) to quickly move the light spot,” said Dr Ohayon. As the fluorescence from each spot travels back through the fibre, an image of neuron activity is formed. Scanning the tiny spot across the sample allows it to excite fluorescent molecules used to label neuron activity. ![]() When light enters the fibre, it can be manipulated to generate a tiny spot at the other end and can be moved to different positions on the tissue without moving the fibre. The new microendoscope is based on a multimode optical fibre, which can carry different multiple beams of light at the same time. “It might also be used to study how neurons from different regions of the brain communicate with each other.” “With further development, the new microendoscope could be used to image neuron activity in previously inaccessible parts of the brain such as the visual cortex of primate animal models,” said Ohayon. One of the advantages of using an endoscope so thin is that as you lower it into the brain, you can see all the blood vessels and navigate the fibre to avoid hitting them ![]()
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